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EC number: 203-041-4
CAS number: 102-60-3
Ethylenediamine, +4PO was assessed for its sensitising effect on the
skin using a Guinea Pig Maximisation Test (GPMT) in a GLP and OECD
guideline 406 study (BASF SE 30H0530/882207, 1989).
During a range finding test, the minimum irritant concentration was
found to be a 50 % and the maximum non-irritant concentration a 25 %
aqueous test substance preparation . 5 % ethylenediamine, +4PO was
applied for intradermal induction followed by epicutaneous induction
using a 50 % test substance preparation. For challenge and rechallenge,
animals were exposed to 25 % ethylenediamine, +4PO. However, challenge
and rechallenge only led to a slight, transient erythema in a single
case. According to the present study, Ethylenediamine, +4PO can thus be
considered as not sensitising to the skin.
Migrated from Short description of key information:
Skin sensitization (OECD 406 & GLP): not sensitising (BASF SE 30H0530/882207; 1989) (GPMT: intradermal induction: 5 %; epicutaneous induction: 50 %; 1. challenge: 25 %; 2. challenge: 25 %)
The available study is
considered reliable and suitable for classification purposes under
67/548/EEC and 1272/2008/EEC. In conclusion, ethylenediamine, +4PO does
not require classification for skin sensitisation.
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