Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-041-4
CAS number: 102-60-3
Pharmocokinetic parameters of ethylenediamine, +4PO:
The data conform to a 'One Compartment Open Model of Distribution'.
Ethylenediamine, +4PO is rapidly (though poorly) absorbed (time to Cpmax
40-45 min) and is virtually 100 % eliminated from the bloodstream within
24 hours following a single dose. The route of excretion is 92-96 % via
renal clearance (average clearance 0.35 ml/hr). The elimination
half-life averaged 108 min, and these data were consistent for doses up
to 200 mg/kg bw. The mean first order elimination rate constant (K) was
0.0064 1/min for dosing with 200 mg/kg bw.
(Vd = volume of distribution; Cl = clearance rate; K = elimination rate
constant; F = bioavailability factor; AUC = Area under the curve)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again