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EC number: 203-041-4
CAS number: 102-60-3
Skin irritation (OECD 404): not irritating (BASF 18H0125/872240; 1987)
Eye irritation (OECD 405): eye irritating (BASF 11H0125/872092, 1987)
The acute skin irritation potential of ethylenediamine, +4PO was
tested in white New Zealand rabbits according to the OECD guideline 404
(BASF SE 18H0125/872240; 1987). 0.5 g test substance were topically
applied to the skin of 3 rabbits for 4 hours under semi-occlusive
dressing. No signs of local skin irritation were reported within the
observation period of 72 h. Thus, the test substance can be considered
as non irritating to the skin.
To assess the acute eye irritation potential of ethylenediamine,
+4PO a study according to OECD guideline 405 was performed in white New
Zealand rabbits (BASF SE 11H0125/872092; 1995). An amount of 0.1 ml test
substance was singly applied to the eyes of three rabbits. The mean
conjuctivae score was 1 and the mean cornea score was 2 in each animal.
The findings were reversible in all animals within 15 days after
application. The mean scores for chemosis and iris were not
Overall, the study can be considered reliable for assessment.
Under the chosen testing conditions, ethylenediamine +4PO shows eye
Effect level: empty Endpoint conclusion: Adverse effect observed
Dangerous Substance Directive (67/548/EEC):
The available study is considered reliable and suitable for
classification purposes under 67/548/EEC. In conlcusion,
ethylenediamine, +4PO does not require classification concerning skin
and eye irritation.
Classification, Labeling, and Packaging Regulation (EC) No.
The available experimental test data is reliable and suitable for
classification purposes under EU Regulation 1272/2008. ethylenediamine,
+4PO does not require classification for skin irritation. The eye
irritating properties are classified as "irritating to eye" cat. 2
according to EU-GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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