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EC number: 203-041-4
CAS number: 102-60-3
Short-term aquatic toxicity studies are available for algae. Data on the
acute toxicity to fish and Daphnia are derived from read-across studies.
The acute toxicity of Ethylendiamine, propoxylated to fish has been
investigated with two freshwater species following procedures similar
to, or according to DIN 38 412, Part 15 protocol (static and
flow-through) at concentrations up to 10,000 mg/l. The 96-h LC50 were
reported as 4,600 (Leuciscus idus, flow through) and 4870 (Brachydanio
rerio, static) mg/l, while the 48-h LC50 was reported as 2,700 (Leuciscus
idus, static) mg/l. Analytical verification of concentrations were
not performed in any of the studies. Based on the available data the
acute toxicity to fish is very low.
Acute toxicity of Ethylendiamine, propoxylated to aquatic invertebrate
was investigated with Daphnia magna following EU procedure C.2 at
a concentration of 100 mg/l. The 24 and 48 hour EC0 value was greater
than 100 mg/l. Analytical verification of concentration was not
performed. The available data indicates low toxicity to aquatic
Toxicity of Ethylenediamine, +4PO to algae has been tested with Desmodesmus
subspicatus over a 72 hr period at concentrations from 0.5 - 100
mg/l. Effect concentration based on growth rate after 72 hrs were:
EC50=150.67, LOEC=8.76 and NOEC= 4.25 mg/l. Analytical verfication of
concentrations ranged from 76.9 to 130% of nominal values at 0 hours,
and from 60.7 to 94% of nominal values at 72 hours.
A long-term toxicity test to aquatic invertebrates is available for the
structurally related substance Ethylenediamine, ethoxylated and
propoxylated: The 21d-NOEC in a OECD 211 guideline study is ≥ 10 mg/l
(nominal) for all endpoints.
Therefore the PNEC assessment is based on the 72h-NOEC determined in D.
subspicatus as the most sensivite chronic endpoint.
Toxicity to microorganisms has been tested with a sample of activated
sludge (from a predominantly domestic water treatment plant) in two
studies over a 3 hour period at nominal concentrations from 100 - 10,000
mg/l. In one study inhibition of 12% was observed at 10,000 mg/L and the
EC50 was > 10,000 mg/l in the other study no effects were observed up to
In a third study, Pseudomonas putida was exposed to varying
concentrations and the 17 hour EC50 was 1400 mg/l, EC10 was 800 mg/l and
EC90 was 2400 mg/l, the TGK (toxicity threshold limit) comparable to the
EC3 value was 800 mg/l.
No-Longer-Polymer (NLP) polyether polyols are produced by the
reaction of various starter molecules with propylene oxide and/or
ethylene oxide. These substances exhibit a remarkable uniformity in the
physical/chemical properties which influence their fate and distribution
in the environment. All NLP polyols have a full acute aquatic
ecotoxicity dataset and do not exhibit acute toxicity below 100 mg/L.
However, differentiation in chronic invertebrate toxicity is apparent
and is based on the alcohol- or amino- starter molecules used to prepare
these NLP polyols. A sub-grouping based on (i) aliphatic alcohol and
amine NLP polyols, (ii) EDA- (ethylenediamine) based amino NLP polyols
and (iii) o-TDA- (orthodiaminotoluene) based
aromatic NLP polyols is justified (ISOPA, 2010) and toxicity is expected
to be similar between substances within each of these categories. It is
considered appropriate to use ‘read-across’ of data of structural
analogues within each sub-grouping to fill data gaps for chronic
invertebrate toxicity and derive PNECs for endpoints based on these
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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