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EC number: 203-041-4 | CAS number: 102-60-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted as the substance can be expected to have a low potential for sorption (log Kow ≤3). The estimated Koc values for structurally analogue substances range from 4.1 to 116 L/kg for the lowest (least sorptive) and highest (most sorptive) molecular weight homologues. The substance can be regarded as having low affinity for adsorption to soils and activated sludge biosolids.
Key value for chemical safety assessment
Additional information
The estimation of log Koc is based on CAS 25214-63-5 a structural analogue of CAS 102 -60 -3.
The KOCWIN software is shown to produce estimated log Koc values which are typically within 0.3 log units of measured values for a set of amine- and alcohol-bearing substances which are expected to have log Koc values bracketing that of the test substance. Because the software training set includes measured Koc values for several aliphatic and aromatic amine substances, it is expected to provide accurate predictions of adsorption for amine-initiated NLP polyols, which may adsorb to soil by a combination of cation-exchange and hydrophobic partitioning mechanisms. These results are therefore expected to provide a more realistic estimation of adsorption potential than the HPLC estimation method, which may be confounded by the surface-activity of the test substance components and lack of relevant reference substances (i.e., alcohols, ethers, amines) employed in the OECD 121 guideline.
Adsorption/Desorption was investigated using the OECD 121 method, and results indicated Koc <17.8 to > 427000 and Log Koc <1.25 to >5.63 over the pH range of 5.5 to 7.5. These results indicate an unexpected high affinity for adsorption of the test substance components, which is contradictory to their very high water solubility, and low log Kow values. Furthermore, because the HPLC method does not account for the cation-exchange mode of adsorption, it may not correctly predict the adsorption of the test substance components which posses cationic amino groups.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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