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EC number: 203-041-4
CAS number: 102-60-3
To determine toxicity to reproduction and prenatal development of
ethylenediamine, +4PO, the test substance was administered to Wistar
rats by gavage (dose levels: 0, 100, 300 and 1000 mg/kg bw; vehicle:
water). Treatment started 14 days before mating. In total, males were
treated for approximately 30 days and females for 49 days. Females and
their pups were sacrificed 4 days post partum. Signs of developmental or
reproductive toxicity were not reported at any dose level (BASF,
Thus the NOAEL for developmental toxicity and toxicity to
reproduction is 1000 mg/kg bw.
Short description of key information:
Reproduction / Developmental Toxicity Screening Test (GLP & OECD 422): NOAEL = 1000 mg/kg bw for developmental toxicity
For details see record "effects on fertility".
The available study is
considered reliable and suitable for classification purposes under
67/548/EEC and 1272/2008/EEC. In conclusion, ethylendiamine, +4PO does
not require classification for developmental toxicity and toxicity to
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