Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-041-4
CAS number: 102-60-3
Short description of key information on bioaccumulation potential result:
absorption: ~ 2 % via intestine
distribution: mainly localised within central compartment (minimal tissue distribution)
metabolism: no metabolites detectable
excretion: 92-96 % by renal excretion; 0.35 ml/h
Pharmacokinetics indicate that ethylenediamine, +4PO is poorly absorbed
from the GI tract (less than 2 %), almost exclusively localized in the
central compartment (plasma water) with negligible binding to albumin or
erythrocytes, minimally biotransformed if at all and removed from the
plasma in a simple first order process. 92 - 96 % ethylenediamine, +4PO
is eliminated via renal excretion with a rate of 0.35 ml/h by simple
glomerular filtration in the absence of tubular reabsorption. The
remaining percentages of Ethylenediamine, +4PO may be removed from the
body by the biliary pathway.
The logPow of -2.08 and the available data of basic toxicokinetics and
acute dermal toxicity (LD50 > 2000 mg/kg bw) do not support a
significant absorption through the skin. Most likely, ethlenediamine,
+4PO will not difíuse through cellular membranes with ease.
Discussion on bioaccumulation potential result:
Ethylenediamine, +4PO's pharmacokinetics indicate that it is rapidly
though poorly absorbed from the GI tract (less than 2 %), almost
exclusively localized in the central compartment (plasma water) with
negligible binding to albumin or erythrocytes and removed from the
plasma in a simple first order process. Ethylenediamine, +4PO is
completely eliminated from the bloodstream within the first 24 h.
Discussion on absorption rate:
The available data of basic toxicokinetics (minimal absorption through
the GI tract), a LogPow of -2.08 and the data on acute dermal toxicity
(LD50 > 2000 mg/kg bw) indicate a negligible absorption through the
skin. The available data support the notion that ehtylenediamine, +4PO
will not difíuse through cellular membranes with ease.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again