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EC number: 203-041-4
CAS number: 102-60-3
Short description of key information on bioaccumulation potential result:
absorption: ~ 2 % via intestine
distribution: mainly localised within central compartment (minimal tissue distribution)
metabolism: no metabolites detectable
excretion: 92-96 % by renal excretion; 0.35 ml/h
Pharmacokinetics indicate that ethylenediamine, +4PO is poorly absorbed
from the GI tract (less than 2 %), almost exclusively localized in the
central compartment (plasma water) with negligible binding to albumin or
erythrocytes, minimally biotransformed if at all and removed from the
plasma in a simple first order process. 92 - 96 % ethylenediamine, +4PO
is eliminated via renal excretion with a rate of 0.35 ml/h by simple
glomerular filtration in the absence of tubular reabsorption. The
remaining percentages of Ethylenediamine, +4PO may be removed from the
body by the biliary pathway.
The logPow of -2.08 and the available data of basic toxicokinetics and
acute dermal toxicity (LD50 > 2000 mg/kg bw) do not support a
significant absorption through the skin. Most likely, ethlenediamine,
+4PO will not difíuse through cellular membranes with ease.
Discussion on bioaccumulation potential result:
Ethylenediamine, +4PO's pharmacokinetics indicate that it is rapidly
though poorly absorbed from the GI tract (less than 2 %), almost
exclusively localized in the central compartment (plasma water) with
negligible binding to albumin or erythrocytes and removed from the
plasma in a simple first order process. Ethylenediamine, +4PO is
completely eliminated from the bloodstream within the first 24 h.
Discussion on absorption rate:
The available data of basic toxicokinetics (minimal absorption through
the GI tract), a LogPow of -2.08 and the data on acute dermal toxicity
(LD50 > 2000 mg/kg bw) indicate a negligible absorption through the
skin. The available data support the notion that ehtylenediamine, +4PO
will not difíuse through cellular membranes with ease.
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