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EC number: 202-895-5
CAS number: 100-85-6
Results dose range finder:
A dose range finder was conducted previously to select dose levels for
the main study and to determine the peak effect of occurrence of
clinical signs after dosing. No testing guidelines were applicable as
dose range finder was intended for dose level selection purposes only.
A dose of 100 mg/kg was not tolerated by the animals as severe clinical
signs, reduced food consumption and mild to severe body weight loss were
observed. All animals treated with 100 mg/kg died before scheduled
necropsy on Day 2, 5 and 6 of treatment. At dose level 25 mg/kg, some
clinical symptoms, reduced food consumption and slight body weight loss
were observed during the 14 Days of treatment. One animal at 25 mg/kg
died at Day 8 of treatment. A dose of 15 mg/kg was well tolerated for 28
days and therefore a maximum dose level of 15 mg/kg was selected for the
main study. Because of the high pH of the test item and its corrosive
properties, the dose volume for the main study was set at 0.072 mL/kg,
based on the dose volume used for the 15 mg/kg Group of the dose range
finder. In the dose range finder, clinical signs were generally observed
directly after dosing.
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