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EC number: 202-895-5
CAS number: 100-85-6
bacterial reverse mutation test was performed according to OECD
guideline 471 and GLP principles to
determine the potential of Benzyltrimethylammonium hydroxide and/or its
metabolites to induce reverse mutations at the histidine locus in
several strains of Salmonella typhimurium (S. typhimurium; TA98, TA100,
TA1535, and TA1537) and at the tryptophan locus of Escherichia coli (E.
coli) strain WP2uvrA in the presence or
absence of S9
-metabolic activation. Bacterial
strains were tested in
the absence and presence of S9-metabolic activation
in two independent experiments, a direct plate assay and a
pre-incubation assay, up to and including the highest recommended
concentration (5 mg/plate). The
negative and strain-specific positive control values were within the
laboratory historical control data ranges indicating that the test
conditions were adequate and that the metabolic activation system (S9
-mix) functioned properly. The test item did not induce a
significant dose-related increase in the number of revertant (His+)
colonies in each of the four tester strains (TA1535, TA1537, TA98 and
TA100) and in the number of revertant (Trp+) colonies in tester strain
WP2uvrA both in the absence and presence of S9-metabolic activation. Based
on the results of this study it is concluded that the test item is not
mutagenic in the Salmonella
mutation assay and in the Escherichia
coli reverse mutation assay.
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