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EC number: 202-895-5
CAS number: 100-85-6
In anin vitroskin corrosion test performed according to OECD 431
and in accordance with GLP principles, the influence of the test
substance on the viability of the human skin was tested using the
EpiDerm Skin Model. BTMAOH in methanl (50 μL) was applied directly on
top of skin tissues and after 3 minutes or 1 hour rinsed away with
phosphate saline buffer. The relative mean tissue viability obtained
after 3-minute and 1-hour treatments with test item compared to the
negative control tissues was 23% and 2.9%, respectively, after
correction for non-specific MTT reduction. Since the mean relative
tissue viability was <50% after the 3-minute treatment, it can be
concluded that the test item is corrosive to the skin. Because the
relative tissue viability after 3 minutes was <25% BTMAOH is classified
as corrosive sub-category 1A.
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