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EC number: 946-365-8
CAS number: -
Number of maternal deaths
14/32 (two replacement dams added on GD6)
Number of litters with viable fetuses
13 (3 litters resorptions only)
8.7 ± 4.6
9.3 ± 3.1
7.9 ± 4.3
0.9 ± 0.9
2.3 ± 4.1
2.0 ± 3.1
4.3 ± 3.7
Fetal body weight (grams)
1.25 ± 0.14
1.24 ± 0.08
1.16 ± 0.11
0.82 ± 0.17
Maternal weight gain
23 ± 2.7
19 ± 8.8
19 ± 5.6
14 ± 6.8
data is being read across from the source study that tested
Hydrocarbons, C9, aromatics based on analogue read across.
This study was conducted to determine the
developmental toxicity of high flash aromatic naphtha. Groups of 30
pregnant female mice were exposed via inhalation to 100, 500, or 1500
ppm of high flash aromatic naphtha for 6 hrs per day during gestation
days 6 -15. The mice were sacrificed on gestation day 18, and examined
for a variety of fetal developmental parameters including number of
viable and nonviable fetuses, number of resorptions, total
implantations, and number of corpea lutea. Animals were also examined
for maternal toxicity signs including body weight, and changes in
appearance and behaviour.
There was a statistically significant
reduction in body weight gain in dams and reduced mean body weight for
fetuses in the 500 ppm exposure group. Therefore, the maternal and
developmental toxicity NOAEC = 100 ppm. The maternal
toxicity LOAEC was 500 ppm based on significant reduction in weight gain
for the dams.
The development toxicity LOAEC was 500 ppm
based on significant reduction in weight gain likely caused by the
significant reduction in maternal body weight.
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