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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
May 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v 3.06). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v 3.06). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism
GLP compliance:
no
Remarks:
The data was calculated by a computer model
Analytical monitoring:
not required
Details on sampling:
No data
Vehicle:
no
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
No data
Test type:
other: QSAR modelled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
No data
Reference substance (positive control):
not required
Key result
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
0.69 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data

The composition used to run the Petrotox model is below, derived from GCxGC data for the substance;

 Carbon Number  MoAr  NMAr  DiAr
 9  73.599  
 10  23.035  1.129  2.237
Validity criteria fulfilled:
yes
Conclusions:
The estimated freshwater fish 28-day NOELR (Loewst Observed Effect Loading Rate) value is 0.69 mg/L based on growth.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater fish 28-day NOELR (Lowest Observed Effect Loading Rate) value is 0.69 mg/L.

Description of key information

Petrotox has been run on the substance Hydrocarbons, C9 -C10, aromatics, >1% Naphthalene and is presented below.

The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C9-C10, aromatics, >1% naphthalene is 0.69 mg/L based on growth.

Key value for chemical safety assessment

Additional information

Hydrocarbons, C9-C10, aromatics, >1% Naphthalene is a hydrocarbon UVCB that, based on available read across data, poses a chronic aquatic hazard. The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

 

The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value for Hydrocarbons, C9-C10, aromatics, >1% naphthalene is 0.69 mg/L, based on growth.