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EC number: 946-365-8
CAS number: -
Summary of other skin sensitisation studies
data is being read across from the source study that tested
Hydrocarbons, C9, aromatics based on analogue read across.
A Hartley dermal sensitization test was
conducted on 30 guinea pigs. Following a preliminary irritation test, 15
Hartley guinea pigs were treated by intradermal injection (0.01 mL; 5.0%
(w/v) vehicle/MRD-83 -208 or with adjuvant) to induce sensitization and
then further sensitized by dermal application of 0.5 ml MRD-83 -208 a
week after the intradermal injection. Guinea pigs were challenged two
weeks later by topical application (0.5 ml 0.5% MRD-83 -208).
No indication of sensitization was noted.
Based on the scored of dermal irritation,
test substance MRD-83 -208 would not be considered a dermal sensitizer
under either EU GHS guidelines or under the EU requirements for
dangerous substances and preparations guidelines.
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