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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption, other
Remarks:
Mathematical Model
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Source of data is from peer reviewed literature. Acceptable well-documented study report which meets basic scientific principles: non-GLP.
Cross-reference
Reason / purpose for cross-reference:
read-across: supporting information
Reference
Endpoint:
dermal absorption, other
Remarks:
Mathematical Model
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Source of data is from peer reviewed literature. Acceptable well-documented study report which meets basic scientific principles: non-GLP.
Reason / purpose for cross-reference:
read-across source
Signs and symptoms of toxicity:
not examined
Dermal irritation:
not examined
Conclusions:
The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
Executive summary:

This data is being read across from the source study that tested Naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene based on analogue read across.

A mathematical model was developed to describe the diffusion coefficients (Dsc) of aromatic hydrocarbons. The diffusion coefficients (Dsc, cm2/min x 10-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.

Data source

Reference
Reference Type:
publication
Title:
Mathematical description of the uptake of hydrocarbons in jet fuel into the stratum corneum of human volunteers.
Author:
Kim, David; Matthew W. Farthing; Cass T. Miller; Nylander-French, Leena A.
Year:
2008
Bibliographic source:
Toxicology Letters 178 (2008) 146-151

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A mathematical description/model was developed to describe the uptake of aromatic hydrocarbons into the stratum corneum of human skin in vivo. The dermal absorption data was gathered in a previous paper (Kim 2006).

Kim, D., Andersen, ME., Nylander-French, L.A., 2006a. Dermal absorption and penetration of jet fuel components in humans. Toxicol. Lett. 165, 11-21.
GLP compliance:
no

Test material

Constituent 1
Constituent 2
Chemical structure
Reference substance name:
Naphthalene
EC Number:
202-049-5
EC Name:
Naphthalene
Cas Number:
91-20-3
Molecular formula:
C10H8
IUPAC Name:
naphthalene
Constituent 3
Chemical structure
Reference substance name:
1-methylnaphthalene
EC Number:
201-966-8
EC Name:
1-methylnaphthalene
Cas Number:
90-12-0
Molecular formula:
C11H10
IUPAC Name:
1-methylnaphthalene
Constituent 4
Chemical structure
Reference substance name:
2-methylnaphthalene
EC Number:
202-078-3
EC Name:
2-methylnaphthalene
Cas Number:
91-57-6
Molecular formula:
C11H10
IUPAC Name:
2-methylnaphthalene
Radiolabelling:
no

Test animals

Species:
human
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
no

Results and discussion

Signs and symptoms of toxicity:
not examined
Dermal irritation:
not examined

Applicant's summary and conclusion

Conclusions:
The diffusion coefficients (Dsc, cm2/min x 10^-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.
Executive summary:

A mathematical model was developed to describe the diffusion coefficients (Dsc) of aromatic hydrocarbons. The diffusion coefficients (Dsc, cm2/min x 10-8) of aromatic hydrocarbons were determined to be: Naphthalene 4.2+/-1.4; 1-Methyl naphthalene 4.6 +/-2.7; 2-Methyl naphthalene 4.5+/-2.6.