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EC number: 946-365-8
CAS number: -
C9-C10, aromatics, >1% Naphthalene are a combination of Hydrocarbons, C9
Aromatics and Hydrocarbons, C10-C12 Aromatics. Read across data is
available for Hydrocarbons, C9 Aromatics and Hydrocarbons, C10-C12
Aromatics and the worst case scenario for each end point has been
Dose Oral 90d – NOAEL = 600 mg/Kg bw for rats (similar to OECD TG 408)
Dose Inhalation 12 month – NOAEC = 900 mg/m3 for rats
(similar to OECD TG 413)
Dose Oral 90d – NOAEL = 300 mg/Kg for rats (similar to OECD TG 408)
Dose Inhalation 12 month – NOAEC = 900 mg/m3 for rats
(similar to OECD TG 413), read-across material Hydrocarbons, C9
In the subchronic study on the oral toxicity
of 1,3,5-TMB, groups of 10 male and 10 female Sprague Dawley rats were
administered via gavage 0, 50, 200, or 600 mg/Kg 1,3,5-TMB in corn oil 5
days/week for 90 days. An additional group of rats (10/sex) were
administered 600 mg/Kg 1,3,5-TMB for 90 days and retained without
treatment for 28 days.
Based on a lack of adverse effects at the
highest dose level (reversible effects such as increased serum
phosphorus levels and liver and kidney weights), the
no-observed-adverse-effect level (NOAEL) for this study is therefore
considered to be 600 mg/Kg/day.
data is being read across from the source study that tested
Hydrocarbons, C10-C13, aromatics, >1% naphthalene based on analogue read
A 90-day subchronic study was conducted in
rats to assess the toxicity of MRD-90-884. The test mixture was
administered by oral gavage at a dose of 0, 300, 600, or 1000 mg/Kg 7
days per week for a period of 13 weeks. The control
animals received a carrier (corn oil) dose and a satellite group was
dosed at 1000 mg/Kg, 7 days/week for 13 weeks and was then observed for
reversibility, persistence or delayed occurrence of toxic effects for 28
days post-treatment. Observations were made as to the
nature, onset, severity, and duration of toxicological signs.
There were a total of 10 animal deaths; four
deaths (1 male, 3 female) at the 1000 mg/Kg dose were attributed to the
treatment. There was an overall low incidence of
clinical signs at the 300 and 600 mg/Kg doses. Low
food consumption and emaciation were observed in animals dosed at 1000
mg/Kg. Post mortem examinations revealed a significant increase in liver
and kidney weights in male and female animals as well as increase in
body weight for all animals except for males in the high dose group. Organ
weight, clinical chemistry, and hematology data from the satellite
recovery group indicated recovery during the 28 day recovery period.
Based on the data recorded in this study,
the NOAEL for MRD-90-884 is 300 mg/Kg.
This study examined the effects of 12 months
of inhalation exposure of rats to a commercial mixture of C9 Aromatics.
Male and female rats were exposed to concentrations of 450, 900, or 1800
mg/m³ 6 hrs/day, 5 days/week, for up to 12 months. Some of the rats were
sacrificed at 26 weeks, others at 12 months, and others after a 4 month
recovery period after the end of the 12 month exposure. Animals were
examined for clinical signs and behaviour twice daily, and weighed
weekly for the first 4 weeks, and monthly thereafter. After sacrifice,
the animals were examined for clinical chemistry, hematology, urine
analysis, gross pathology, histopathology, and organ weights.
No deaths attributable to exposure to the
test substance occurred. There was depressed weight during the first few
months of the experiment in medium (900 mg/m³) and high dose males (1800
mg/m³). However, the animals quickly recovered and this effect is not
considered biologically significant. High dose females (1800 mg/m³) had
depressed weight gain for the first 3 months of exposure, but recovered
in subsequent months and in the satellite recovery group. No other
adverse effects attributable to exposure to the test substance were
Based on the reversibility of the reduced
weight gain and the lack of any noted pathology, the NOAEC for male rats
was 1800 mg/m³ and the NOAEC for female rats was 900 mg/m3.
Twenty-five male rats and four dogs per
level were exposed for 6 hr/day, 5 days/wk for 13 wk. Another 20 rats,
from the same week of production, were maintained for use as challenge
exposure controls (naive rats). The challenge exposures were run to
determine whether the 6-hr daily inhalation of a non-lethal level of
hydrocarbon, would result in the rat becoming more or less resistant.
One rat at the 0.10-mg/liter level died
after 14 days. Death was attributed to a pneumonic infection as
evidenced by extensive lung abscesses. None of the observations were
dosage-related and are discounted for that reason. The test material’s
NOAEC > 0.38 mg/liter (66 ppm), which was the highest achievable vapor
C9 aromatics are expected to have a low order of repeated dose toxicity
by the oral route of exposure. All tests were performed in a manner
to currently established OECD guidelines. In a repeated dose study where
the test substance, Hydrocarbons, C9 aromatics, was administered via
oral gavage, no toxicity was observed and characterized at the highest
dose tested of 600 mg/Kg. Based on this observation, the repeat oral
dose NOAEL is 600 mg/Kg for C9 Aromatics.
In a 12 month chronic study where Hydrocarbons, C9 aromatics were
administered via inhalation, the NOAEC for male rats was determined to
be 1800 mg/m3, the
concentration tested. The NOAEC for female rats was determined to be 900
mg/m3, due to the reduced body weight noted.
Aromatics are expected to have a low order of repeated dose toxicity by
the oral route of exposure. All tests were performed in a manner similar
or equivalent to
established OECD guidelines. In a repeated dose study where the test
substance, C10-C12 Aromatics, was administered via oral gavage, signs of
toxicity were observed and characterized at doses of 600 mg/Kg. The
severity and frequency of the responses increase with increasing
doses. Noted changes include alterations to hematology (hematocrit,
hemaglobin, MCHC), changes to thyroid follicular epithelial cells, and
increases in the hemosiderin in macrophages. The effects had reversed
completely after the 4-week recovery period. Based on these
observations, the repeat oral dose NOAEL is 300 mg/Kg for C10-C12
In a 12 month repeated dose study where the read-across substance
Hydrocarbons, C9 Aromatics were administered via inhalation, the NOAEC
for male rats was
to be 1800 mg/m3, the highest concentration tested. The NOAEC
for female rats was determined to be 900 mg/m3, due to the
reduced body weight noted.
is no data available for Hydrocarbons, C9-C10, aromatics, >1%
Naphthalene. Hydrocarbons, C9-C10, aromatics, >1% Naphthalene are a
combination of Hydrocarbons, C9 Aromatics and Hydrocarbons, C10-C12
Aromatics. Based on available read across data, Hydrocarbons, C9-C10,
aromatics, >1% Naphthalene do not warrant classification as a repeated
dose toxicant under Regulation (EC) 1272/2008 on classification,
labelling and packaging of substances and mixtures (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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