Registration Dossier

Toxicological information

Carcinogenicity

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Description of key information

A non-oxidative hair dye formulation containing 0.5% 1-naphthol together with 12 other dye ingredients has been tested for carcinogenicity in mice and rats by topical application. No increase in tumour frequency was found. No conclusion with regard to carcinogenicity can, however, be made from the studies due to the low concentration of 1-naphthol used and the fact that the experimental procedure used did not give any response when 2,4 -diaminoanisole (EU, carcinogenic Category 2) was tested.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

A non-oxidative hair dye formulation containing 0.5% 1 -naphthol has been tested for carcinogenicity in mice and rats by topical application. No increase in tumour frequency was found. No conclusion with regard to carcinogenicity can, however, be made from the studies due to the low concentration of 1 -naphthol used.