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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1980
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Version / remarks:
Not specified
Principles of method if other than guideline:
General description has several elements of scientific requirements for this type of study
GLP compliance:
not specified
Test type:
traditional method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Specific details on test material used for the study:
Test item is identified with the CAS number from the information given in the IUCLID2003 Dataset.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Details on inhalation exposure:
Two types of doses / exposures are mentioned. One under the L0 determination (Saturated atmosphere of chemical vapor), and another under the LC50 determination (Saturated atmosphere of mist, vapor and decomposition products) as described under the study design
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
Not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
Exposure type: Saturated atmosphere of chemical vapor:

Substantially saturated vapor was prepared by spreading 50-100 grams of 1-naphthol over a 200 cm2 area on a shallow tray placed near the top of a 120 liter plexiglas chamber which is then sealed for at least 16 hours while an intermittently operated fan agitates the internal chamber atmosphere. Rats were then introduced into a gasketed drawer-type cage designed and operated to minimize vapor loss. Animals were exposed for six (6) hours and observed for mortality and toxicity for 14 days.

Exposure type: Saturated atmosphere of mist, vapor and decomposition products:

1-naphthol was heated to 179 degree C. Air was passed over the heated sample and mist, vapor, and any oxidation products generated were delivered to rats in a 9 liter glass exposure chamber. Animals were exposed for six (6) hours. Animals were observed for mortality and toxicity for 14 days.

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC0
Exp. duration:
6 h
Remarks on result:
not determinable
Remarks:
No mortality or signs of toxicity in rats exposed to a saturated vapor atmosphere.
Sex:
not specified
Dose descriptor:
LC50
Exp. duration:
6 h
Remarks on result:
not determinable
Remarks:
No mortality when rats exposed to s saturated vapor atmosphere of heated 1-naphthol. Signs of toxicity included eye irritation and hypoactivity
Mortality:
None
Clinical signs:
other: Signs of toxicity included eye irritation and hypoactivity when rats were exposed for 6 hours to a saturated vapor atmosphere of heated 1-naphthol.
Body weight:
Not described
Gross pathology:
Not described

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
STOT SE Cat 3 (Note, this is also a harmonized classification)
Conclusions:
LC50 not determinable as the concentrations were not provided. However, STOT SE Cat 3 was assigned per UN GHS due to the eye irritation and hypoactivity from exposure to heated saturated vapor. No mortality reported.
Executive summary:

Rats were exposed for 6 hours with saturated atmosphere of 1 -naphthol or a saturated atmosphere of mist, vapor, and decomposition products of heated (179 degrees C) 1 -naphthol. The LC50 was not reported and the exposure concentrations were not provided. No deaths occured. The results cannot be used for Acute Toxicity - inhalation classification. However, STOT SE Cat 3 was assigned per UN GHS due to the hypoactivity from exposure to heated saturated vapor of 1 -naphthol.