Registration Dossier

Administrative data

Endpoint:
long-term toxicity to fish, other
Remarks:
calculation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
Remarks:
ECOSAR predicts a higher value for chronic fish than the experimental test data available from acute fish studies (0.58 vs 0.33 mg/L, respectively)

Data source

Reference
Reference Type:
other: calculation
Title:
ECOSAR v1.11
Author:
EPA
Year:
2017
Bibliographic source:
ECOSAR (Ecological Structure-Activity Relationship) Class Program for Microsoft Windows v.1.11 (24 July 2012). U.S. Environmental Protection Agency. Office of Chemical Safety and Pollution Prevention.

Materials and methods

Principles of method if other than guideline:
calculation

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Results and discussion

Effect concentrations
Duration:
36 d
Dose descriptor:
other: ChV
Effect conc.:
0.838 mg/L
Remarks on result:
other: ECOSAR v1.11 calculation, Phenols class

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
The calculated (ECOSAR v1.11, Phenols class) ChV (36d) is 0.838 mg/L. ECOSAR predicts a higher value for chronic fish than the experimental test data available from acute fish studies (0.58 vs 0.33 mg/L, respectively)
Executive summary:

The calculated (ECOSAR v1.11, Phenols class) ChV (36d) is 0.838 mg/L.  ECOSAR predicts a higher value for chronic fish than the experimental test data available from acute fish studies (0.58 vs 0.33 mg/L, respectively)