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Surface tension

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Reference
Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 27 May 2016 to 23 September 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 115 (Surface Tension of Aqueous Solutions)
Deviations:
no
GLP compliance:
yes
Type of method:
ring method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: A017 / Lot Number ADT1214003
- Expiration date of the lot/batch: TBD
- Purity test date: 27 May 2016
Re-analysis date : 08 June 2016 and Purity : 98.9%
Re-analysis date : 08 September 2016 and Purity : 99.2%
The purity is unchanged and remains 98.9%

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
- Stability under test conditions: yes
- Solubility and stability of the test substance in the solvent/vehicle: yes
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: no

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no
- Preliminary purification step (if any): no
- Final dilution of a dissolved solid, stock liquid or gel:
A test substance stock solution was prepared on 25 august 2016 by weighing 201.0 mg of the test substance into a 200-mL volumetric flask. The flask was then brought to volume with distilled water and sonicated to mix.
- Final preparation of a solid: no

FORM AS APPLIED IN THE TEST (if different from that of starting material)
Solid dissolved in distilled water
Key result
Surface tension:
ca. 60.1 other: dynes/cm
Temp.:
20.3 °C
Conc.:
1.005 g/L
Remarks on result:
other: 60.1 ± 0.82 dynes/cm at 20.3 ± 0.1 ºC

The temperature during the definitive test ranged from 20.2 to 20.4°C. The true surface tension of the test substance was determined to be 60.1 ± 0.82 dynes/cm at a temperature of 20.3 ± 0.1 ºC. Reproducibility was demonstrated as evidenced by the coefficient of variance (CV), which was 1.36%. The results are presented in the following table:

 Sample  

Elapsed Time (min)

 Apparent Surface Tension (dynes/cm)  Calibration correction Factor Instrument correction Factor   

True Surface

Tension

(dynes/cm)

 Replicate 1  4  67.8  0.971  0.928  61.1
   7  66.9    0.971  0.927  60.2
   10  66.8    0.971   0.927  60.1
 Replicate 2  5  65.5    0.971  0.926  58.9
   8  65.3    0.971  0.925  58.7
   11  66.5    0.971  0.927  59.9
 Replicate 3  5  68.4    0.971  0.928  61.6
   7  67.1    0.971  0.927  60.4
   10  66.9    0.971  0.927  60.2

Overal Mean : 60.1 ± 0.82

Percent CV 1.36

Conclusions:
The true surface tension of the A017 solution was determined to be 60.1 ± 0.82 dynes/cm at a temperature of 20.3 ± 0.1 ºC.
Executive summary:

The surface tension of A017 was determined according to the OECD 115 guideline and the GLP.

The Surface tension was measured with a Fisher Scientific Surface Tensiomat Model 21.

The true surface tension of the A017 solution at the concentration of 1.005 g/L was determined to be 60.1 ± 0.82 dynes/cm at a temperature of 20.3 ± 0.1 ºC.

Description of key information

The true surface tension of the A017 solution was determined to be 60.1 ± 0.82 dynes/cm at a temperature of 20.3 ± 0.1 ºC.

Key value for chemical safety assessment

Surface tension:
60.1
in mN/m at 20°C and concentration in mg/L:
1 005

Additional information

The surface tension of A017 was determined according to the OECD 115 guideline and the GLP.

The Surface tension was measured with a Fisher Scientific Surface Tensiomat Model 21.

The true surface tension of the A017 solution at the concentration of 1.005 g/L was determined to be 60.1 ± 0.82 dynes/cm at a temperature of 20.3 ± 0.1 ºC.