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EC number: -
CAS number: -
See attached document.
guideline 405 and EC Method B.5 (Acute Toxicity: Eye Irritation /
New Zealand White female rabbits were exposed to 0.1 mL of test item in
the right eye while the left eye remained untreated and served as
control. The eyelids were then gently held together for one second
before releasing. The eyes were examined and the changes were observed
at 1, 24, 48 and 72 h after treatment and graded according to the Draize
No corneal effects were noted during the
study. Iridial inflammation was noted in both treated eyes 1 hour after
treatment. Moderate conjunctival irritation was noted in both treated
eyes 1 and 24 hours after treatment. Moderate conjunctival irritation
persisted in one treated eye with minimal conjunctival irritation noted
in the other treated eye at the 48 hour observation. Minimal
conjunctival irritation was noted in both treated eyes at the 72 hour
observation. Both treated eyes appeared normal at the 7-day observation.
One animal showed a body weight loss and
the other animal showed an expected gain in body weight during the
The substance is irritating to the eye of
rabbits. Under the test conditions, the substance is classified as
irritating to eyes according to CLP Regulation (EC) No. 1272/2008.
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