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EC number: -
CAS number: -
Individual body weights and body weight changes:
Dose level mg/kg
Animal number and sex
Body weight (g) at Day
Body weight gain (g) during week
OECD Guideline 402 and EC Method B.3 (Acute Toxicity Dermal)
A group of ten Wistar (RccHanTM:WIST) rats (5 males and 5
females) were given a single dermal application of test item at 2000
mg/kg bw. The test item was placed directly on back and flanks of the
skin representing approximately 10 % of the total body surface of the
animals. The test site was then covered by a semi-occlusive dressing for
24 h. Animals were then observed for mortality, clinical signs and
bodyweights for 14 days.
No mortality and no clinical signs were observed during the study. There
were no signs of dermal irritation. All animals showed expected gains in
body weight over the observation period. No macroscopic abnormalities
were observed at necropsy. The combined dermal LD50 was considered to be
higher than 2000 mg/kg bw in rats.
Under the test conditions, the acute median dermal LD50 is higher than
2000 mg/kg bw in rats therefore it is not classified according to CLP
Regulation (EC) No. 1272/2008.
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