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EC number: -
CAS number: -
Individual skin reactions
Observation Time (following patch removal)
Individual score – Rabbit number and sex
Sum of 24 and 72-hour readings (S): 4
Primary Irritation Index (S/4): 4/4 = 1.0
Classification: MILD IRRITANT
( ) = Total values not used for calculation of primary irritation index
Individual body weights and body weight change
Rabbit number and sex
Individual body weight (kg)
Body weight change (kg)
guideline 404 and EC Method B.4 (Acute Toxicity: Dermal Irritation /
Zealand White female rabbits were dermally exposed to 0.5 mL of the test
material for 4 h under a semi-occlusive dressing. After removal of the
residual test item, irritation was scored immediately following removal
of the patches and approximately 1, 24, 48 and 72 h later, according to
slight erythema was noted at one treated skin site 1 hour after patch
removal and at both treated sites at the 24, 48 and 72 hour observations.
treated skin sites appeared normal at the 7 day observations.
corrosive effects were noted.
animals showed expected gain in body weight during the study.
item produced a primary irritation index of 1.0.
test conditions the substance is not classified as irritating to skin
according to CLP Regulation (EC) No. 1272/2008.
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