Registration Dossier

Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1985
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available

Data source

Reference
Reference Type:
publication
Title:
Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program
Author:
Yoon, J.S. et al.
Year:
1985
Bibliographic source:
Environ Mutagen. 7(3):349-67.

Materials and methods

Principles of method if other than guideline:
Drosophila Sex-Linked Recessive Lethal Study
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2,3-Dichloronitrobenzene
- Analytical purity: no data

Test animals

Species:
Drosophila melanogaster
Strain:
other: not applicable
Sex:
male/female

Administration / exposure

Route of administration:
other: no data
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Examinations

Tissues and cell types examined:
no data

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Any other information on results incl. tables

No further information given.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative