1,2-dichloro-3-nitrobenzene

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study. Basic data given.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

A QSAR study of the toxicity of nitrobenzene derivatives towards Daphnia magna, Chlorella pyrenoidosa and Photobacterium phosphoreum

Author:

Deneer JW, van Leeuwen CJ, Seinen W, Maas-Diepeveen JL, Hermens JLM

Year:

1989

Bibliographic source:

Aquatic Toxicology 15: 83-98

Reference 2

Reference Type:

secondary source

Title:

1,2-Dichlornitrobenzole (1,2-Dichlor-3-nitrobenzol, 1,2-Dichlor-4-nitrobenzol)

Author:

BUA (Beratergremium umweltrelevanter Altstoffe) (BUA)

Year:

1990

Bibliographic source:

Gesellschaft Deutscher Chemiker (Hrsg Behret) Bd 52, VCH (Verlag Chemie), Weinheim

Reference 3

Reference Type:

publication

Title:

Parametric analysis of population growth in bio-assays.

Author:

Kooyman SALM, Hanstveit AO, Oldersma H

Year:

1983

Bibliographic source:

Water Res. 17, 527-538

Reference 4

Reference Type:

publication

Title:

Aquatic Toxicological Aspects of Dithiocarbamates and related Compounds. I. Short-term Toxicity Tests

Author:

van Leeuwen CJ, Maas-Diepeveen JL, Niebeek G, Vergouw WHA, Griffioen PS, Luijken MW

Year:

1985

Bibliographic source:

Aquatic Toxicology 7: 145-164

Materials and methods

Test guideline

Qualifier:

according to

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Version / remarks:

, 1984

Deviations:

yes

Remarks:

: slight modifications according to Van Leeuwen et al., 1985

GLP compliance:

not specified

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Name of test material (as cited in study report): 2,3-Dichloronitrobenzene
- Analytical purity: not given

Sampling and analysis

Analytical monitoring:

not specified

Test organisms

Test organisms (species):

Chlorella pyrenoidosa

Study design

Water media type:

freshwater

Total exposure duration:

96 h

Test conditions

Nominal and measured concentrations:

Test concentrations increased geometrically with a factor of 3.2.

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

2.9 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

biomass

Any other information on results incl. tables

- the result published in the paper is log EC50 = 1.18 µmol/l

- the result mentioned above was calculated by the applicant based on the reported log IC50

Applicant's summary and conclusion

Executive summary:

Deneer et al.(1989) determined the effect of 2,3-dichloronitrobenzene on the population growth of Chlorella pyrenoidosa, as described in the OECD guideline 201 (1984), including some slight modifications indicated elsewhere (van Leeuwenet al., 1985). The 96h-log EC50 was 1.18 µmol/l corresponding to an EC50 of 2.9 mg/l.