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EC number: 202-993-8
CAS number: 101-97-3
The test substance was found to have no
sensitizing effect on the skin.
The skin sensitizing potential of the test
item was tested in the open epicutaneous test with guinea pigs. The test
was conducted on groups of 6 -8 male and female animals weighting 300
-450 grams. Daily applications were made for 3 weeks to a clipped 8 cm2
area on the flank of each guinea pig. The test sites were not covered
and the reactions were read 24 hours after each application. A total of
21 applications of 0.1 mL test material in an unspecified vehicle were
made for 21 days. The 10 controls were either left untreated or treated
with 0.1 mL of the vehicle for 21 days. At the challenge phase, both the
test and control animals were treated at some lower primary
non-irritating concentrations. On the basis of these resulst, the test
substance was considered to be non sensitising. This result is supported
by results of skin sensitization tests on humans, as described in this
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