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EC number: 202-993-8
CAS number: 101-97-3
The partition coefficient log Pow of the test substance was determined to be log Pow = 2.36 at 22 °C
A study was conducted in accordance
with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine
the partition coefficient of the test substance. Using the HPLC method
partition coefficient Pow was determined in two individual measurements.
Therefore a stock solution of the test item in methanol was prepared. A
test solution was prepared by dilution the mobile phase (55 % methanol
and 45 % water (v/v). The resulting solution of 10 mg/L pH 6-7 was
directly measured via HPLC-UV at 22 ± 1 °C. The reference items were
measured twice, once before and once after the measurement (double
injection of one replicate) of the test item. The void time of the HPLC
system was determined with sodium nitrate. For each reference item, the
capacity factor K was calculated from the retention time of sodium
nitrate and the retention time of the respective reference item. A
calibration function (log K versus log Pow, linear fit) was determined
using the literature values for Pow of the reference items and the
retention times in the six determinations. Two individual log POW values
for the test item were derived under consideration of the first and
second calibration. Finally, a mean value was calculated from these
individual log POW values. The coefficient of determination r2 of the
calibration function log K/Log Pow was calculated to be 0.9836 and
0.9850 respectively. According to the guideline criteria these value was
considered as sufficient to use the calibration function for the
determination of the log Pow of the test item. The retention time of the
test item lied within the range of the reference items. The log Pow of
the test substance was determined to be 2.36 at 22 °C. All validation
criteria ere fulfilled and no observations were made which might cause
doubts concerning the validity of the study outcome.
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