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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity studies on rats and rabbits
Author:
Moreno O.M.
Year:
1973
Bibliographic source:
Unpublished report to RIFM. Report 2021
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl phenylacetate
EC Number:
202-993-8
EC Name:
Ethyl phenylacetate
Cas Number:
101-97-3
Molecular formula:
C10H12O2
IUPAC Name:
ethyl phenylacetate

Test animals

Species:
rabbit
Sex:
not specified

Administration / exposure

Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 animals (total numer of animals, sex not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
1/10
Clinical signs:
In 5/10 animals anorexia on days 1, 2
1/10 animals extreme weakness prior to death

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute dermal toxicity study the LD50 was determined to be >5000 mg/kg bw.
Executive summary:

The acute dermal toxicity of the test item was determined. The study was conducted with 10 rabbits. They received a dermal application of 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. One of 10 animals died during the study. The calculated LD50 was determined to be >5000 mg/kg bw. Toxic effects were found in 5/10 animals on days 1 and 2. They showed signs of anorexia. An extreme weakness was found in 1 animal prior to death.