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EC number: -
CAS number: -
All treated animals survived the scheduled
study period and no signs of toxicity were observed.
A test item is regarded as a sensitiser in
the LLNA if the exposure to one or more test concentration resulted in
3-fold or greater increase in incorporation of 3HTdR compared with
concurrent controls, as indicated by the Stimulation Index (S.I.). The
estimated concentration of test item required to produce a S.I. of 3 is
referred to as the EC3 value.
In this study Stimulation Indices of 2.11,
4.47, and 4.80 were determined with the test item at concentrations of
25, 50, and 100% in acetone:olive oil (4 :1). The EC3 value calculated
In the study the test item dissolved in
acetone:olive oil (4+1) was assessed for its possible contact allergenic
For this purpose a local lymph node assay
was performed using test item concentrations of 25, 50, and 100%.
The animals did not show any clinical signs
during the course of the study and no cases of mortality were observed.
In this study Stimulation Indices (S.I.) of
2.11, 4.47, and 4.80 were determined with the test item at
concentrations of 25, 50, and 100% in acetone:olive oil (4 :1),
The test item was found to be a skin
sensitiser in this assay and an EC3 value of 34.4% was derived.
According to the Regulation (EC) No
1272/2008 on classification, labeling and packaging (CLP) of substances
and mixtures, the test item should be classified as skin sensitiser
According to the ECETOC classification
scheme for potency (ECETOC Technical Report No. 87, Contact
sensitization: Classification according to potency, April 2003,
Brussels), the test item would be regarded as weak sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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