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Per REACH Guidance 8.4.2 the different
exposure time (7 days/week in the experiment; 5 days/week for workers)
were corrected by multiplying a factor of 7/5. According to Example R.
8-2 Workers, this time correctet oral NOAEL of 1400 mg/kg/day (28 days
Repeated Dose Toxicity Test) was converted to an inhalation equivalent:
1400 mg/kg/day ÷ 0.38 m3/kg bw (8 h exposure – rat) × 6.7 m³ (8 h
exposure – human) ÷ 10 m³ (worker respiratory volume [wRV] - 8 h) = 2450
Per REACH Guidance 8.4.2 (Example R. 8 -1
General Public), the oral NOAEL of 1000 mg/kg/day (28 days Repeated Dose
Toxicity Test) was converted to an inhalation equivalent: 1000 mg/kg/day
÷ 1.15 m3/kg bw (24 h exposure – rat) = 970 mg/m³.
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