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Per REACH Guidance 8.4.2 the different
exposure time (7 days/week in the experiment; 5 days/week for workers)
were corrected by multiplying a factor of 7/5. According to Example R.
8-2 Workers, this time correctet oral NOAEL of 1400 mg/kg/day (28 days
Repeated Dose Toxicity Test) was converted to an inhalation equivalent:
1400 mg/kg/day ÷ 0.38 m3/kg bw (8 h exposure – rat) × 6.7 m³ (8 h
exposure – human) ÷ 10 m³ (worker respiratory volume [wRV] - 8 h) = 2450
Per REACH Guidance 8.4.2 (Example R. 8 -1
General Public), the oral NOAEL of 1000 mg/kg/day (28 days Repeated Dose
Toxicity Test) was converted to an inhalation equivalent: 1000 mg/kg/day
÷ 1.15 m3/kg bw (24 h exposure – rat) = 970 mg/m³.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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