Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study well documented, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Toxicity studies of certain organic peroxides and hydroperoxides
Author:
Floyd EP, Stokinger HE
Year:
1958
Bibliographic source:
Am Ind Hyg Assoc J 19: 205-212

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
7 weeks
Frequency of treatment:
three times weekly (monday, wednesday, friday)
Doses / concentrations
Remarks:
Doses / Concentrations:
19 mg/kg (one-fifth of LD50)
Basis:

No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

4/5 died; loss of weight; the pelage was coarse in most rats after first week of treatment

Applicant's summary and conclusion

Conclusions:
The repeated oral application of one-fith of LD50 of cumene hydroperoxide was toxic to rats
Executive summary:

Cumene hydroperoxide (one-fifth of LD50) was given orally to rats three times weekly for seven weeks; 4/5 animals died; the rats lost weight and the pelage was coarse.