Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
4 weeks
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study report which meets basic scientific principles (doses not provided)

Data source

Reference
Reference Type:
publication
Title:
Toxicity studies of certain organic peroxides and hydroperoxides
Author:
Floyd EP, Stokinger HE
Year:
1958
Bibliographic source:
Am. In. Hyg. Assoc. J. 19: 205-212

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
5 rats were exposed to 4 geometrically spaced dose levels. LD50 determined according to Weil (1952, 1953)
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
73% purity (minimum); no further information available

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses:
specific doses were not provided, 4 geometrically spaced dose levels that included 400 mg/kg because effects at this dose level were mentioned
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
382 mg/kg bw

Any other information on results incl. tables

Extensive urinary bleeding, death within 5 d, no weight loss

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Cumene hydroperoxide was tested for its acute oral toxicity in rats; the oral LD50 was approximately 382 mg/kg bw; extensive urinary bleeding was observed at doses of 400 mg/kg bw.