Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1952

Materials and methods

Principles of method if other than guideline:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
other: undiluted or diluted in Dowanol 50B
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data

Results and discussion

Any other information on results incl. tables

Material

No. of

applications

Site

Rating - Response

100%

2

Ear

Moderate hyperemia, edema, necrosis

100%

1

Abdomen

Severe edema and necrosis, slight denaturation

10% sol.

10

Ear

Slight hyperemia, scaliness, crustation

10% sol.

4

Abdomen

Severe hyperemia and edema, moderate necrosis

1% sol.

10

Ear

Very slight hyperemia and scaliness

1% sol.

10

Abdomen

Moderate hyperemia and scaliness

0.1% sol.

10

Ear

Very slight hyperemia and scaliness

0.1% sol.

10

Abdomen

Sight scaliness

Applicant's summary and conclusion

Conclusions:
Cumene hydroperoxide undiluted and its strong solutions are severely irritating to the skin
Executive summary:

Cumene hydroperoxide was tested for skin irritation in rabbits; the undiluted substance and its strong solutions were severely irritating causing hyperemia, edema and necrosis