Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: collection of data

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Eye irritation was tested on rabbit. The test substance was instilled undiluted or in propylene glycol.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: undiluted or diluted in propylene glycol
Controls:
not specified
Duration of treatment / exposure:
24 h
Observation period (in vivo):
24 h
Number of animals or in vitro replicates:
5

Results and discussion

Any other information on results incl. tables

0.005 ml undiluted chemical: severe corneal injury with iritis and necroid eylids; 5% solution: moderate corneal injury with iritis; 1% solution: no corneal injury

Overall evaluation: Grade 9, severe

Applicant's summary and conclusion

Conclusions:
Cumene hydroperoxyde caused severe eye irritation
Executive summary:

Cumene hydroperoxide was tested for eye irritation in rabbits; instillation of small amounts of undiluted substance caused severe eye irritation with corneal injury, iritis and necroid eyelids