Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
6 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
5.25
Modified dose descriptor starting point:
NOAEC
Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

The American Industrial Hygiene Association (AIHA) derived a Workplace Environmental Exposure Level (WEEL) guide

for the occupational exposure. The starting point was the NOAEL (31 mg/m3) of the 3 -month inhalation performed in rats (Dow, 1979) in which signs of irritation of the respiratory tract and mucous membranes were observed at higher concentrations. In addition animals exposed to 16 ppm for 12 days experienced irritation, however, all organs were normal (Gage, 1970). Dermal carcinogenicity studies were negative. Thus, a WEEL guide of 1 ppm as an 8 -hr time-weighed average should prevent irritation and systemic effects workers. The DNEL long-term for systemic and acute local effects is 1 ppm (6 mg/m3).

References:

Workplace Environmental Exposure Level guide : Cumene hydroperoxide (AIHA 1991)

Gage, J.C.: the subacute inhalation toxicity of 109 Industrial Chemicals. Br. J. Ind. Med.27:11 (1970).

Dow Chemical Co. U.S.A.: a 90-Day repeated inhalation study of cumene hydroperoxide in rats (1979). Unpublished study. Dow Chemical Co. U.S.A., Midland, MI 48674.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

No DNELs will be derived for the General Population. The exposure of General Population is expected to be low.