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Diss Factsheets
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EC number: 200-855-1 | CAS number: 75-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The key repeated dose oral toxicity study (HSDB 2002 citing Jeong 2002), which was not conducted in accordance with the applicable OECD Guideline or GLP, showed immunitoxicity to cells in the male rat spleen and thymus at 1,000 mg/kg bw/day (LOAEL) 2-bromopropane ingested daily for 28 consecutive days. No adverse effects were observed at 330 mg/kg bw/day (NOAEL) during the same exposure period.
The key repeated dose inhalation toxicity study (JBRC 1999), which was conducted according to OECD 422 and to GLP, showed decreases in male testis weight in the rat following 6-hour daily exposure to 2-bromopropane for 14 consecutive days at a vapour concentration of 1,000 ppm (LOAEC). No adverse effects were observed at 500 ppm (NOAEC) during the same exposure period.
Supporting documentation from genetic toxicity and toxicity to reproduction studies indicated that repeated exposure to 2-bromopropane resulted in adverse effects.
Key value for chemical safety assessment
Additional information
For repeated dose oral and inhalation toxicity, the most recent reliable study was selected as the key study.
Justification for classification or non-classification
Based upon the available studies for repeated exposures via ingestion and inhalation, 2-bromopropane does not require classification as STOT-RE Category 1 or 2 as described in EC No 1272/2008, because the LOAEL and LOAEC determined in the key studies were higher than the guideline value ranges. Labeling as R48/20 (Harmful: Danger of Serious Damage to Health by Prolonged Exposure Through Inhalation) is appropriate based upon the body of evidence.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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