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EC number: 260-828-5
CAS number: 57583-34-3
Oral: LD50 880 mg/kg (rat)
Inhalation: LC50 240 mg/L (1 hour exposure; rat)
Dermal: LD50 1000 mg/kg in female rabbits; LD50 2150 mg/kg in
The acute oral toxicity of undiluted Methyltin tris
(2ethylhexylthioglycolate) was evaluated in compliance with the
conditions specified in the regulation for the enforcement of the
Federal Insecticide, Fungicide, and Rodenticide Act (40 CFR), the Toxic
Substances Control Act (40 CFR) and OECD Guideline 401.
The test material was administered undiluted to groups of five male and
five female Sprague Dawley rats at a dose level of 3.15 g/kg, 1.25 g/kg,
0.80 g/kg, and 0.50 g/kg. Following a single oral administration, the
animals were observed for 14 days.
Based on the mortality observed, the acute oral LD50 value was
calculated to be 0.88 g/kg with the 95% Confidence Limits of 0.67 g/kg
and 1.15 g/kg. Clinical signs noted during the observation period
included varying degrees of depression, comatose, piloerection, eye
squinting, hunched posture, labored breathing, ataxia, fecal stains,
urine stains, and masticatory movement. All surviving animals exhibited
body weight gain at day 14. Gross necropsy findings for animals that
died during the observation period included lungs pale, reddened, or
mottled, liver mottled, liver pale and mottled with lower edge of lobes
of liver darkened, areas of liver exhibit white blanching, areas of
liver pale, spleen pale, darkened, or mottled, pancreas darkened,
kidneys pale and/or congested, kidneys enlarged, stomach distended with
gas, intestines reddened, intestines distended with gas, intestines
contain a viscous yellow to orange fluid, urinary bladder contains a
pale red fluid, and external staining. No gross pathological changes
were noted in animals that survived the observation period.
The slope was 1.22 (1.04-1.43)
Groups of 10 rats, both male and female, inhaled the test material
within a closed chamber of known volume. The test material was sprayed
into the chamber by means of an atomiser. Animals were observed for 3
Gross autopsy findings included: blood in the lungs, dark spleen, pale
kidneys, fluid in the chest cavity and heart failure.
The inhalation LC50 was 240 mg/L/h.
Females- Body Weight (g)Animal no. Skin condition Day 0 Day 15 Body Weight Gain Day 0-15 (g)215 mg/kg15 abraded 2904 3209 30516 intact 3201 3568 367Mean (SD) 3052 (210) 3388 (254) 336 (44)464 mg/kg11 abraded 2783 2895 11212 intact 2758 3065 307Mean (SD) 2770 (18) 2980 (55) 210 (138)1000 mg/kg3 abraded 3280 rabbit died prior to observation4 intact 2649 3051 402Mean (SD) 2964 (446) 3051 4022150 mg/kg7 abraded 2955 rabbit died prior to observation8 intact 2629 rabbit died prior to observationMean (SD) 2792 (231)
The test material was applied undiluted to the skin of sixteen New
Zealand White rabbits (two males and two females per dose level) at
dosages of 0.215, 0.464, 1.0, 2.15 (females) or 1.0, 2.15, 4.64 and 10.0
g/kg (males) for 24 hours. Animals were observed for gross signs of
systemic toxicity, dermal irritation, and death for 14 days. At the end
of the 14day observation period, survivors were weighed, killed, and
given a gross necropsy.
Deaths occurred between days 3 and 6 of the observation period. Clinical
changes associated with the test material included death, shaking
behavior, uncoordinated movement, ataxia and hypersensitivity. The most
frequently observed irritative effects included erythema, edema, atonia,
desquamation and blanching. Gross necropsies performed on the animals
that died revealed irritated gastrointestinal tracts, pale or congested
kidneys and reddened lungs. Gross necropsies performed on survivors at
the end of the study revealed no gross alterations. The acute dermal
LD50 value was found to be 2.15 g/kg in male and 1.0 g/kg in female New
Zealand White rabbits.
The acute oral LD50 of MMT(2-EHMA) was 880 mg/kg in rats.
The study was considered reliable. In this study, the LD50 was 880 (95 %
CI 670 to 1150) mg/kg. Mortality rates for both sexes were 1/10, 4/10,
8/10, and 10/10 for dose levels of 500, 800, 1250, and 3150 mg/kg,
respectively. At 0.50 and 0.80 g/kg no males died. One 0.50 g/kg female
was dead at 24 hours. At 0.80 g/kg, 2 females were dead at 24 hours and
2 were dead at 48 hours. Three males and 4 females of the 1.25 g/kg
group were dead at 24 hours and 1 female at 48 hours. Five males and 5
females of the 3.15 g/kg group were dead at 24 hours.
Clinical observations included depression, comatose, piloerection, eye
squinting, hunched posture, laboured breathing, ataxia, faecal/urine
stains, and masticatory movement. No gross pathological changes were
reported in surviving animals.
The acute inhalation LC50 of MMT(2-EHMA) was 240 mg/L.
The study reported an acute inhalation LC50 of 240 (212 to 271) mg/L in
a 1-hr aerosol exposure to male and female rats. The mortality rate was
2/10, 6/10, 9/10 and 10/10 animals at dose levels of 200, 250, 300 and
250 mg/L/hr, respectively. Gross findings included blood in lungs, dark
spleen, pale kidneys, fluid in the chest cavity, and heart failure. The
slope of the dose-response curve was 1.22 (1.04 to 1.43).
The acute dermal LD50 of MMT(2-EHMA) in rabbits was 1000 (460 to 2020)
mg/kg for females and 2150 (1000 to 4620) mg/kg for males. There were no
deaths at 215 and 464 mg/kg, 0/2 males and 1/2 females died at 1000
mg/kg and 1/2 males and 2/2 females died at 2150 mg/kg. All animals died
at 4640 and 10 000 mg/kg. A variety of clinical abnormalities were
observed and disappeared in surviving animals by the end of the exposure
period. Clinical signs included death, uncoordinated movements, shaking,
and hypersensitivity to external stimuli.
Gross necropsy results for animals that died during the study included
irritated intestines; blanched stomach; reddened lungs; pale or
congested kidneys; and oral, ocular and/or nasal discharges.
In accordance with the criteria for classification as defined in
Annex I, Regulation (EC) No 1272/2008, the substance requires
classification with respect to acute toxicity via the oral and dermal
routes as Acute toxicity Category 4 and 3, respectively (H302:
Harmful if swallowed; H311: Toxic in contact with skin).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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