Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Neurotoxicity

Currently viewing:

Administrative data

Description of key information

In a guideline 90-day subchronic dietary study conducted in Wistar rats, effects occurred at the high dose of 750 ppm (equivalent to 49.7 mg/kg bw/day in males and 53.6 mg/kg bw/day in females), which consisted of changes in neurobehavioral parameters and associated brain histopathology, and changes in hematology, clinical chemistry, urinalysis, organ weights, and pathology of the thymus. The NOAEL was the next lower dose of 150 ppm (equivalent to 9.8 mg/kg bw/day in males and 10.2 mgkg bw/day in females).
In a Developmental Neurotoxicity study, the NOAEL of 94.3 mg/kg/day is based on treatment-related brain vacuolization at all doses. No functional effects were seen.
There was no NOAEL in a behavioral screening study in drinking water. Runway learning and swim escape effects were observed.

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Dose descriptor:
NOAEL
9.8 mg/kg bw/day

Additional information

Justification for classification or non-classification