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Toxicity to microorganisms

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Description of key information

Hydrolysate of methyl chloroformate (Methanol, HCl, CO2): The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.

Key value for chemical safety assessment

Additional information

The hydrolysate (3 -d hydrolysis) of methyl chloroformate was tested in a GLP study following OECD TG 209. The EC50 (30 min) was determined to be > 1000 mg/L, related to nominal concentrations of the parent compound (BASF AG, 1999).

Hydrolysis product methanol: In a respiration inhibition test with activated sludge following OECD TG 209, the 3 -h EC50 was determined to be > 1000 mg/L (Kleĉka et al., 1985).

Species

Results

Remarks

Reference

Activated sludge, domestic

EC50 (30 min) > 1000 mg/L (nominal), OECD TG 209

Hydrolysate (3 -d; Methanol, HCl, CO2); reliability: 1, key study

BASF AG, 1999

Activated sludge, domestic

EC50 (3 h) > 1000 mg/L (nominal); OECD 209 respiration inhibition test

Hydrolysis product methanol; reliability: 2, key study

Kleĉka et al., 1985