Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Principles of method if other than guideline:
diferent concentrations of the testsubstance were injected i.p. into mice
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
0.0681-3 .16% aqueous solution
Control animals:
not specified
Details on study design:
Determination of the approximative median lethal dose or LD50 calculated according to LITCHFIELD-WILCOXON
- Duration of observation period following administration: 14

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
ca. 9 other: µl
Clinical signs:
Dyspnea; apathy; staggering in some cases; twitching in some cases; poor general sate
Gross pathology:
Intraabdominal adhesions sporadically

Applicant's summary and conclusion