Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 July - 21 July, 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed according to OECD and/or EC guidelines, and according to GLP principles.
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
Pow
Partition coefficient:
> 3 200 000
Temp.:
25 °C
pH:
ca. 7
Key result
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
25 °C
pH:
ca. 7
Details on results:
The components of the test substance eluted with retention times of > 2 minutes. The retention time of 2,4-DDT was 2.01 minutes. Hence, it was concluded that the log Pow of the components of the test substance was > 6.5 (Pow > 3.2E 6).

Using 75/25 (v/v) methanol/water as the mobile phase and when injecting the HXL-8366 solution in methanol it was confirmed that none of the HXL-8366 peaks elute before 2,4-DDT.
Conclusions:
Using the HPLC method, the Pow and log Pow values of HXL-8366 are > 3.2E6 and > 6.5, respectively.

Description of key information

The Pow and log Pow values of HXL-8366 are > 3.2E6 and > 6.5, respectively.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.5
at the temperature of:
20 °C

Additional information

Using the HPLC method, the Pow and log Pow values of HXL-8366 are > 3.2E6 and > 6.5, respectively.