Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The study has been performed according to OECD and EC guidelines and according to GLP principles. The data relating to the identity, purity and stability of the test material are not mentioned in the test report but can be retrieved from the original NONS notification.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report Date:
1999

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Annex V
GLP compliance:
yes
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): CETEC 2254
- Physical state: straw coloured liquid
- Analytical purity: not indicated

Test animals

Species:
other: Rat (Sprague-Dawley)

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: Test material was used as supplied.
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No signs of systemic toxicity were noted during the study.
Gross pathology:
Effects on organs:
No abnormalities were noted at necropsy. No signs of skin
irritation were noted during the study. No deaths were
recorded.
Other findings:
Signs of toxicity (local):
No signs of skin irritation were noted during the study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU