1-(2-hydroxy-5-nonyl(branched)-phenyl)ethanone oxime

Specific investigations: other studies

Administrative data

Endpoint:

endocrine system modulation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: according to P. Sohoni and J.P. Sumpter (1998)

Principles of method if other than guideline:

The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.

GLP compliance:

no

Type of method:

in vitro

Test material

Test material information

Constituent 1

Reference substance name:

1-(2-Hydroxy-5-nonyl(branched)-phenyl)ethanone oxime

EC Number:

627-083-1

Cas Number:

244235-47-0

IUPAC Name:

1-(2-Hydroxy-5-nonyl(branched)-phenyl)ethanone oxime

Details on test material:

- Name of test material: C9 Ketoxim
- Physical state: Liquid, greygreen, clear
- Analytical purity: >90%
- Storage condition of test material: Room temperature

Test animals

Species:

other: yeast

Administration / exposure

Vehicle:

DMSO

Results and discussion

Details on results:

In this study, the test substance C9 Ketoxim showed no androgenic activity in comparison to dihydrotestosterone.
In this study, the test substance C9 Ketoxim showed clear antiandrogenic activity from about 10-6 mol/L onward in comparison to hydroxyflutamide.
No cytotoxicity was observed.