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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: endocrine system modulation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: recent study conducted according to reliable in-house protocol

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: according to P. Sohoni and J.P. Sumpter (1998)
Principles of method if other than guideline:
The aim of the study was to determine the androgenic and antiandrogenic potential of C9 Ketoxim. The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: C9 Ketoxim
- Physical state: Liquid, greygreen, clear
- Analytical purity: >90%
- Storage condition of test material: Room temperature

Test animals

Species:
other: yeast

Administration / exposure

Vehicle:
DMSO

Results and discussion

Details on results:
In this study, the test substance C9 Ketoxim showed no androgenic activity in comparison to dihydrotestosterone.
In this study, the test substance C9 Ketoxim showed clear antiandrogenic activity from about 10-6 mol/L onward in comparison to hydroxyflutamide.
No cytotoxicity was observed.

Applicant's summary and conclusion