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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

NOELr (21d) = 2.8 mg/L (nominal, WAF) for reproduction of Daphnia magna (OECD 211)

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
2.8 mg/L

Additional information

One study investigating the long-term toxicity of the test substance to aquatic invertebrates is available. The study was performed according to GLP and OECD guideline 211 using Daphnia magna as test organism (Wehrhahn 2010). Test solutions ranging from 0.18 to 7.0 mg/L were prepared by direct adding test substance to the test medium, 24h stirring and subsequent filtering. The test organisms were exposed for 21 days under semi-static conditions. As the analytical measurements were not reproducible (probably due to low water solubility and hydrolysis), nominal concentrations were reported. All validity criteria (no immobilised Daphnia in control group with a mean offspring of 104 (> 60) and a variation of CV=7.3%) were met. No significant immobility was observed, while effects on reproduction rate of Daphnia magna were observed at nominal 7.0 mg/L. Thus, the lowest 21d-NOELR value was obtained for reproduction and is determined to be 2.8 mg/L loading rate WAF.