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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

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Description of key information

NOEC (112d) = 90 mg/kg dw (nominal) for soil community (semi-field study, read across)

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for soil macroorganisms:
90 mg/kg soil dw

Additional information

Since no study assessing the long-term toxicity of Ethanone, 1-(2-hydroxy-5-nonylphenyl)-, oxime, branched (CAS 244235-47-0) to soil macroorganisms is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to Phenol, 4-nonyl-,branched was conducted, which is a secondary component and structurally similar to the main component of the substance. The only structural difference between the source substance and the target substance is the lack of a ketoxime group at the phenol ring of the molecule.

The read across is justified due to the following reasons:

1) The similarity of structure and functional groups and accordingly similar physico-chemical properties result in similar environmental behavior and fate.

2) Based on a profound ecotoxicological data set available for Phenol, 4-nonyl-,branched it can be concluded that Phenol, 4-nonyl-,branched exhibit a higher aquatic toxicity compared to Ethanone, 1-(2-hydroxy-5-nonylphenyl)-, oxime, branched (see table below). Therefore, using data from Phenol, 4-nonyl-,branched to assess the intrinsic hazard of Ethanone, 1-(2-hydroxy-5-nonylphenyl)-, oxime, branched is considered to be a very conservative approach (worst case scenario).

Substance

Ethanone, 1-(2-hydroxy-5-nonylphenyl)-, oxime, branched

Phenol, 4-nonyl, branched*

CAS number

244235-47-0

84852-15-3

Structure

see attachment (chapter 6.3)

 see attachment (chapter 6.3)

Molecular formula

C17H27NO2

C15H24O

Molecular weight

~ 277 g/mole

~ 220.35 g/mole

PC parameter

 

 

Water solubility

> 0.02 < 1 mg/L (EU method A.6)

5.7 mg/L (ASTM E 1148-02)

Partition coefficient

> 5.7(EU method A.8)

5.4 (OECD 117)

Vapour pressure

< 1.5 Pa at 20 °C (OECD 104)

~1 Pa at 20 °C (ASTM-D 2879)

Environmental fate

 

 

Biodegradability

1 % in 28 days (BODIS)

non-adapted inoculum:

0 % in 28 days (OECD 301B)

 

adapted inoculum:

48.2-62 % in 28 days (OECD 301B)

Adsorption [log KOC]

3.9 (OECD 121)

4.35 - 5.69 (EPA OTS 796.2750)

Hydrolysis

not relevant

Ecotoxicology

 

 

Short-term toxicity to fish

[96h-LC50]

0.46 mg/L (EU method C.1)

0.05 – 0.22 mg/L (different methods)

Long-term toxicity to aquatic invertebrates

[NOEC]

-

0.006 mg/L (ASTM E 1241-05)

Short-term toxicity to aquatic invertebrates

[48h-EC50]

9.55 mg/L (OECD 202)

0.08 – 0.14 mg/L (different methods)

Long-term toxicity to aquatic invertebrates

[21d-NOEC]

2.8 mg/L (OECD 211)

0.024 - 0.116 mg/L (different methods)

Short-term toxicity to algae

[72h-EC50]

760 mg/L(OECD 201)

0.33 - 1.3 mg/L (different methods)

Long-term toxicity to algae

[72h-NOEC/EC10]

472 mg/L (OECD 201)

0.5 mg/L (Algal growth inhibition test according to UBA 1984)

Toxicity to microorganisms

[EC50]

> 1000 mg/L (OECD 209)

950 mg/L (OECD 209)

* Data were taken from Phenol, 4-nonyl-,branched (CAS 84852-15-3) dossier published on the ECHA data base

 

The effect of increasing 4-nonylphenol (NP) concentrations (0, 10, 30, 90, and 270 mg/kg) in soil microcosms containing a simplified soil community was investigated over three sampling dates (28, 56, and 112 days) using the principal response curves method (Domene et al. 2010). The soil community did not change significantly at concentrations below 90 mg/kg, which was selected as the nonobserved effect concentration (NOEC). The highest concentration (270 mg/kg) changed the community significantly after 28 and 56 days, but this effect disappeared after 112 days.

Based on the reasons given above this value is considered to be sufficiently conservative to be used for the hazard assessment of Ethanone, 1-(2-hydroxy-5-nonylphenyl)-, oxime, branched (CAS 244235-47-0).