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EC number: 627-083-1
CAS number: 244235-47-0
Hydrolysis is a negligible removal process for Ethanone,
1-(2-hydroxy-5-nonylphenyl)-, oxime, branched (CAS 244235-47-0) in the
In accordance with Annex XI, subitem 2. Testing
is technically not possible, of Regulation (EC) No.
1907/2006, testing for hydrolysis as a function of pH
may be omitted, if the test is technically not
possible to conduct. The substance is very poorly
soluble in water (> 0.02 < 0.1 mg/L determined in an
appropriate test method [VTA34N00003.01] which
complies with EU method A.6, see 4.8 for details). In
order to improve the solubility in water, a stock
solution of the test item is prepared in acetone (50
mg test substance in 2 mL). When adding the stock
solution to 1000 mL of water, a white precipitate is
produced immediately. Thus, the test is technically
not possible to conduct, since the practical
insolubility of the test substance impedes a proper
In addition, the EU Risk Assessment Report
(2002) states that hydrolysis is a negligible removal
processes for nonylphenol in the aquatic environment.
This assumption is based upon the stability of
nonylphenol during storage and several biodegradation
studies reviewed by the UK rapporteur on behalf of the
European Union where no degradation was observed in
the control experiments. The authors of these studies
concluded that abiotic degradation was likely to be
negligible (Corti et al. 1995, Trocmé et al. 1988;
both cited in the EU Risk Assessment Report 2002).
Based on the structural similarity this conclusion is
also considered to be true for Ethanone,
1-(2-hydroxy-5-nonylphenyl)-, oxime, branched (CAS
This is confirmed by one study investigating the
abiotic degradation (hydrolysis as a function of pH)
potential of the structurally similar Benzaldehyde,
2-hydroxy-5-nonyl, oxime, branched (CAS 174333-80-3).
This study was performed according to OECD guideline
111 under GLP conditions (BASF 2018). The test was
performed at different pH values over an exposure time
of up to 790 h. Hydrolysis is very slow and reduced to
the oxime group and thus do not significantly modify
the structural characteristic and subsequently the
(eco)toxicological potential of the substance. Hence,
the hydrolysis products do not have to be considered
separately in the hazard assessment. in conclusion,
abiotic hydrolysis is not considered to be a relevant
degradation pathway of the substance at
environmentally relevant conditions (e.g.,
Based on the structural similarity the same conclusion
can be drawn for Ethanone,
1-(2-hydroxy-5-nonylphenyl)-, oxime, branched.
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