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EC number: 627-083-1
CAS number: 244235-47-0
The plates incubated with the test item showed reduced background growth
with and without S9 mix in all strains used.
Toxic effects, evident as a reduction in the number of revertants (below
the indication factor of 0.5), occurred in the test groups with and
without metabolic activation.
No substantial increase in revertant colony numbers of any of the five
tester strains was observed following treatment with the test substance
at any dose level, neither in the presence nor absence of metabolic
activation (S9 mix). There was also no tendency of higher mutation rates
with increasing concentrations in the range below the generally
acknowledged border of biological relevance.
Appropriate reference mutagens were used as positive controls and showed
a distinct increase of induced revertant colonies.
registered substance has
been tested in a GLP-study according to OECD test guideline 471.
The strain salmonella typhimurium TA 98, 100, 102, 1535 and 1537 were
used without and with metabolic activation by S9. Appropriate,
strain-specific controls were used giving valid results. The test
substance was applied in suspension.
As the test substance did not give any positive result, it is considered
not to be mutagenic.
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