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Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to an appropriate EU test method and in compliance with GLP but full details are not available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test material (as cited in study report): Silane, Triethoxy [2-(7-oxabicyclo[4.1.0]hept-3-yl)-ethyl CAS 10217-34-2
Molecular formula: C13H26O4Si
Molecular weight: 274,43
Physical state: Clear, pale liquid
Analytical purity: 100% (two isomers)
Lot/batch no: 16465-80
Expiration date of the lot/batch: 1999-01-06
Stability under test conditions: Stable
Storage condition of test material: At room temperature in the dark
density: 1.00

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
4.1
Temp.:
23 °C
Remarks on result:
other: major isomer
Type:
Pow
Partition coefficient:
130 000
Temp.:
23 °C
Remarks on result:
other: major isomer
Type:
log Pow
Partition coefficient:
5
Temp.:
23 °C
Remarks on result:
other: minor isomer
Type:
Pow
Partition coefficient:
96 000
Temp.:
23 °C
Remarks on result:
other: minor isomer

Applicant's summary and conclusion

Conclusions:
In conclusion, the octanol-water partition coefficient values of 4.1 and 5.0 were obtained for the isomers of 2-(3,4-epoxycyclohexyl)ethyltriethoxy silane using a HPLC method.