Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 425-050-4 | CAS number: 10217-34-2
The acute dermal toxicity of Y-4036 was evaluated in this single-dose study in albino rats. The test material was administered once dermally at a dose of 2000 mg/kg to the clipped, intact skin of five male and five female albino rats for a 24 -hour exposure period under semi-occlusive dressing.
Mortality, clinical observations, dermal findings, body weights and gross necropsy findings were evaluated. There were no deaths, test material-related clinical findings or remarkable body weight changes. The test material induced very slight erythema on nine animals and very slight edema on three animals. Five rats had desquamation. There were no other dermal findings. All dermal irritation completely subsided by day 8 or earlier.
Reddened cervical lymph node(s) were observed in seven out of ten rats at the terminal necropsy. While the 70% incidence of this finding is suggestive of a test material-related effect, given the limited scope of this study and the absence of other effects, its toxicological significance is unclear. There were no other gross necropsy findings.
The LD50 of Y-4036 was found herein to be greater than 2000 mg/kg when applied once for 24 hours to the clipped, intact skin of male and female albino rats. In addition, the 2000 mg/kg dose level was found to be a NOEL for systemic toxicity under the conditions of this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again