Registration Dossier
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EC number: 445-040-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Due to the high water solubility and the low logP value, dermal uptake will be very unlikely and a ratio of 0.1 for oral to dermal absorption is therefore used for DNEL derivation. For the oral and inhalatory route, the default absorption values from the REACH guidance (Chapter 8, R.8.4.2) are used for DNEL derivation, namely: 100% for inhalation, and 50% for oral absorption.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 5
- Absorption rate - inhalation (%):
- 100
Additional information
Since no toxicokinetic studies are available for the test substance the following assessment is based on the available physicochemical properties and results from other toxicological studies.
The test substance is a dark red brownish powder with a high molecular weight. The log Pow value is <-5.5 and the solubility in water is ≥419 g/L.
Gastrointestinal absorption: Water-soluble substances may readily dissolve into the gastrointestinal fluids. However, absorption of very hydrophilic substances by passive diffusion may be limited by the rate at which the substance partitions out of the gastrointestinal fluid. The high molecular weight of the test substance does also not favor absorption. However, in the 28-days repeated dose study, slightly lower mean body weights in males treated with 200 mg/kg bw/day and 1000 mg/kg bw/day during the treatment period, passive fecal and urine discoloration, as well as minor macroscopical discoloration of some tissues of the excretory pathway was observed. Thus the test substance will be absorbed by the gastrointestinal tract.
Dermal absorption: The high water solubility (>10000 mg/L) and the log Pow lower than -1 suggests that the substance may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Furthermore, in the available acute dermal study, no effects were observed. Therefore, dermal uptake will be very unlikely and aratio of 0.1 for oral to dermal absorption is therefore used for DNEL derivation.
Respiratory absorption: No experimental data is available concerning the respiratory hazard of the test substance. However, generally, water soluble dust would readily diffuse/dissolve into the mucus lining of the respiratory tract. Furthermore, signs of systemic toxicity present in the oral toxicity study indicates the potential for absorption following ingestion and it is therefore likely that the substance will also be absorbed if it is inhaled.
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