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EC number: 445-040-3 | CAS number: -
In a GLP compliant dermal toxicity study, performed according to OECD guideline 402, Wistar rats (5/sex) were treated with the test substance (2000 mg/kg bw) by dermal application. The test substance was diluted in vehicle (water), administered on the skin with a syringe and covered with a semi-occlusive dressing for 24 hours. After 24 hours the dressing was removed and the skin was flushed with lukewarm tap water. A 14-day observation period followed. No deaths occurred during the study and no macroscopic findings were observed. Light red discoloration of the treated skin area produced by the test item was observed in all male and female animals. Two females showed a loss of body weight (0.5% and 0.6%) between test day 1 and 8 and another female showed also a loss of body weight (0.3%) between test day 8 and the end of the observation period. The body weight of the remaining female and all male animals was within the range commonly recorded for this strain and age. Based on the observations, the LD50 of the test substance is greater than 2000 mg/kg bw.
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